They identified two proteins, MreB and CcmA, that balance cell-wall production in the right areas. pylori maintains its helical shape by targeting cell-wall synthesis to two areas with opposite curvature properties. In new work published in the open-access journal eLife, scientists at Fred Hutchinson Cancer Research Center revealed that H. A deeper understanding of how different bacterial species pattern themselves could provide the insights needed to develop better-targeted antibiotics.
pylori make itself helical? It’s a fundamental question with practical applications: many antibiotics, including penicillin, interfere with the integrity of bacterial cell walls. The bacterium’s shape is dictated by the shape of its cell wall, a strong, flexible meshwork that contains its cellular contents. pylori under the microscope the bug’s corkscrew form is critical to its ability to escape stomach acid and anchor in for the long haul by swimming through the stomach’s mucus lining. Its shape doesn’t just help scientists spot H. pylori’s defining characteristics is right there in its name: its helical shape. About half of the world’s population is chronically infected with the bacterium, which burrows its way into the mucus lining the stomach and sets up long-term inflammation that can trigger ulcers and, more rarely, cancer. One of the main risk factors for this disease is infection with the bacterium Helicobacter pylori. Stomach cancer is the third-leading cause of cancer-related death across the globe.
Institutional Partners & Collaborations.Vaccine and Infectious Disease Division.
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